He along with Admiral Zhao, Squat, Baboo and Darkonda to face the Majestic Guardians in the final battle to prevent them from saving Miguel and Tulio and Chel. But he was turned to dust along with the other revived villains and his soul was returned back to the afterlife by Morto.
He has green eyes, pale tan skin. he wore a mask to cover his mouth and wore green pants.
- MAjestic Guardians: Revenge of Tzekel Kan (debut)
- He and Hidan makes a immortal duo when they were together. But they did not get along well due to Hidan being pious to his savage religion while Kakuzu cares only about making money, which caused them to be annoyed with one another.
- In Naruto series, he was brought back by Kabuto Yakushi during the Fourth Great Ninja War. In the Majestic Guardians series, he was brought back by Tzekel Kan.
- Kakuzu's dub actor, Fred Tatasciore, is well known for being the current voice of the Hulk.